Colin Farrell (Alexander), Angelina Jolie (Olympias), Val Kilmer (Philipp II.), Anthony Hopkins (Ptolemaios), Rosario Dawson (Roxanne), Jared Leto (Hephaestion), Christopher Plummer (Aristoteles), Erol Sander (Prinz Pharnakes), Gary Stretch (Kleitos), Jonathan Rhys Meyers (Kassander), Ian Beattie (Antigonos), Brian Blessed (Leonidas), Connor Paolo (junger Alexander), Elliot Cowan (junger Ptolemaios), Laird Macintosh (Neoptolomos), Raz Degan (Dareios III.), Rory McCann (Krateros), Bin Bunluerit (Poros, König von Indien), Michael Dixon (Dimnos), Jaran Ngamdee (indischer Prinz), Francisco Bosch (Bagoas), Joe Morgan (Philotas)