Denzel Washington (Frank Lucas), Russell Crowe (Richie Roberts), Ted Levine (Lou Toback), Cuba Gooding jr. (Nicky Barnes), Josh Brolin (Detective Trupo), Chiwetel Ejiofor (Huey Lucas), Carla Gugino (Laurie Roberts), Joe Morton (Charlie Williams), Common (Turner Lucas), T.I. (Stevie Lucas), Kevin Corrigan (Campizi), Yul Vazquez (Alfonso Abruzzo), Ruben Santiago-Hudson (Doc), RZA (Moses Jones), Ritchie Coster (Joey Sadano), Idris Elba (Tango), John Hawkes (Freddie Spearman), KaDee Strickland (Richies Verteidiger), Ruby Dee (Mama Lucas), Armand Assante (Dominic Cattano), Malcolm Goodwin (Jimmy Zee), Jon Polito (Rossi), John Ortiz (Javier J. Rivera), Norman Reedus (Detective im Leichenschauraum), Kathleen Garrett (Mrs. Dominic Cattano), Tom O'Rourke (Banker), Jim R. Coleman (Gerichtsvollzieher), Roger Guenveur Smith (Nate), Robert Funaro (McCann), Jon DeVries (Anwalt James Racine), Skyler Fortgang (Michael Roberts), Quisha Saunders (Darlynn), Melissia Hill (Redtop), J. Kyle Manzay (Dexter Lucas), Albert Jones (Terrence Lucas), Warner Miller (Melvin Lucas), Lymari Nadal (Eva), Bari K. Willerford (Joe Louis)