Morgan Freeman (Theodore Joadson), Anthony Hopkins (John Quincy Adams), Nigel Hawthorne (Präsident Martin Van Buren), Matthew McConaughey (Roger Baldwin), Djimon Hounsou (Joseph Cinque), Pete Postlethwaite (Ankläger Holabird), Stellan Skarsgård (Lewis Tappan), Anna Paquin (Königin Isabella), David Paymer (Außenminister John Forsyth), Razaaq Adoti (Yamba), Tomas Milian (Calderon), Chiwetel Ejiofor (James Covey), Geno Silva (Ruiz), John Ortiz (Montes), Peter Firth (Captain Fitzgerald), Ralph Brown (Lieutenant Gedney), Darren E. Burrows (Lieutenant Meade), Allan Rich (Richter Juttson), Jeremy Northam (Richter Coglin), Paul Guilfoyle (Anwalt), Xander Berkeley (Hammond), Arliss Howard (John C. Calhoun), Abu Bakaar Fofanah (Fala), Derrick N. Ashong (Buakei)