Tom Hanks (Jim Lovell), Bill Paxton (Fred Haise), Kevin Bacon (Jack Swigert), Gary Sinise (Ken Mattingly), Ed Harris (Gene Kranz), Kathleen Quinlan (Marilyn Lovell), Joe Spano (NASA-Direktor), Mary Kate Schellhardt (Barbara Lovell), Emily Ann Lloyd (Susan Lovell), Miko Hughes (Jeffrey Lovell), Jean Speegle Howard (Blanch Lovell), Tracy Reiner (Mary Haise), Chris Ellis (Slayton), Rance Howard (Reverend), David Andrews (Pete Conrad), Max Elliott Slade (Jay Lovell), Brett Cullen (Capcomann), Xander Berkeley (Henry Hurt), Roger Corman (Kongressabgeordneter), Clint Howard (Sy Liebergot), Thom Barry (Krankenpfleger), Ray McKinnon (Jerry Bostick), Endre Hules (Guenter Wendt), Marc McClure (Glynn Lunney), Brian Markinson (Pad Rat), Steve Rankin (Pad Rat), Loren Dean (John Aaron), Christian Clemenson (Dr. Chuck), John Wheeler (Reporter), Paul Mantee (Reporter), Thomas Crawford (Reporter), Frank Cavestani (Reporter), Meadow Williams (Kim), Max Grodenchik (FIDO-Gold), Googy Gress (RETRO-White), Jane Jenkins (Nachbarin), Austin O'Brien (kluges Kind), Ben Marley (John Young)