Bruce Willis (Harry S. Stamper), Ben Affleck (A.J. Frost), Liv Tyler (Grace Stamper), Billy Bob Thornton (Dan Truman), Will Patton (Charles 'Chick' Chapple), Steve Buscemi (Rockhound), Jason Isaacs (Dr. Ronald Quincy), William Fichtner (Colonel Willie Sharp), Owen Wilson (Oscar Choi), Michael Clarke Duncan (J. Otis 'Bear' Kurleen), Peter Stormare (Lev Andropov), David Keith (General Kimsey), Greg Collins (Lt. Halsey), Grace Zabriskie (Dottie), Udo Kier (Psychologe der NASA), Jessica Steen (Co-Pilotin Jennifer Watts), Chris Ellis (Walter Clark), Ken Hudson Campbell (Max Lennert), Clark Heathcliffe Brolly (Freddy Noonan), Eddie Griffin (Little Guy)