Jennifer Aniston (Claire Bennett), Adriana Barraza (Silvana), Anna Kendrick (Nina Collins), Sam Worthington (Roy Collins), Mamie Gummer (Bonnie), Felicity Huffman (Annette), William H. Macy (Leonard), Chris Messina (Jason Bennett), Lucy Punch (Schwester Gayle), Britt Robertson (Becky), Allen Maldonado (Buddy), Alma Martinez (Irma), Andrew Elvis Miller (Grenzpolizist), Ashley Crow (Stephanie), Camille Guaty (Tina), Camille Mana (Schwester Salazar), Julio Oscar Mechoso (Apotheker), Laura Putney (Klinikangestellte), Evan O'Toole (Casey Collins), Misty Upham (Liz), Manuel Garcia-Rulfo (Arturo), Paula Cale (Carol), Pepe Serna (Nuncio), Rose Abdoo (Innocencia), Clayton Frey (junger Patient)