Matt Damon (Jason Bourne / David Webb), Julia Stiles (Nicky Parsons), David Strathairn (Noah Vosen), Scott Glenn (Ezra Kramer), Paddy Considine (Simon Ross), Albert Finney (Dr. Albert Hirsch), Edgar Ramirez (Paz), Joan Allen (Pam Landy), Tom Gallop (Tom Cronin), Daniel Brühl (Martin Kreutz), Chris Cooper (Alexander Conklin), Joey Ansah (Desh), Mark Bazeley (Betancourt), Scott Adkins (Agent Kiley), Charles Venn (Agent Hammond), Branko Tomovic (russischer Polizist), Laurence Possa (russischer Polizist), Lucy Liemann (Lucy), Colin Stinton (Neal Daniels), Jeffrey Lee Gibson (Vosens Chauffeur), Dan Fredenburgh (Jimmy), Kai Martin (Hoody), Sinead O'Keeffe (Chamberlain), Russ Huards (Techniker), John Roberson (Techniker), Bryan Reents (Techniker), Arkie Reece (Techniker), Corey Johnson (Wills)