Jeremy Renner (Aaron Cross / Kenneth James Kitsom / Nummer 5), Rachel Weisz (Dr. Marta Shearing), Edward Norton (Colonel Eric Byer, US Air Force), Joan Allen (Deputy Director Pamela Landy), David Strathairn (Noah Vosen), Albert Finney (Dr. Albert Hirsch), Louis Ozawa Changchien (LARX-03), Scott Glenn (Ezra Kramer), Oscar Isaac (Nummer 3), Stacy Keach (Admiral Mark Turso, US Navy), Corey Johnson (Ray Wills), Corey Stoll (Vendel), Dennis Boutsikaris (Terrence Ward), Donna Murphy (Dita), Michael Chernus (Arthur Ingram), Page Leong (Mrs. Yun), Neil Brooks Cunningham (Dr. Dan Hillcott), Sonnie Brown (Dr. Lieberburg), Tony Guida (Dr. Benezara), Zeljko Ivanek (Dr. Donald Foite)