Jodie Foster (Clarice Starling), Anthony Hopkins (Dr. Hannibal Lecter), Ted Levine (Jame Gumb / 'Buffalo Bill'), Brooke Smith (Catherine Martin), Scott Glenn (Jack Crawford), Anthony Heald (Dr. Frederick Chilton), Diane Baker (Senatorin Ruth Martin), Kasi Lemmons (Ardelia Mapp), Charles Napier (Lieutenant Boyle), Tracey Walter (Lamar), Dan Butler (Roden), Frankie Faison (Barney Matthews), George A. Romero (FBI-Agent in Memphis), Roger Corman (FBI-Direktor Hayden Burke), Stuart Rudin (Miggs), Ron Vawter (Paul Krendler), Paul Lazar (Pilcher), Pat McNamara (Sheriff Perkins), Gene Borkan (Oscar), Bill Miller (Mr. Brigham), Chuck Aber (Agent Terry), Lawrence T. Wrentz (Agent Burroughs), Kenneth Utt (Dr. Akin), Leib Lensky (Mr. Lang)