Ralph Fiennes (M. Gustave H.), Fahrid Murray Abraham (Mr. Moustafa), Mathieu Amalric (Serge X.), Adrien Brody (Dmitri), Willem Dafoe (Jopling), Jeff Goldblum (Vilmos Kovacs), Harvey Keitel (Ludwig), Jude Law (Schriftsteller (jung)), Tom Wilkinson (Schriftsteller (alt)), Bill Murray (M. Ivan), Edward Norton (Henckels), Saoirse Ronan (Agatha), Jason Schwartzman (M. Jean), Tilda Swinton (Madame D.), Owen Wilson (M. Chuck), Larry Pine (Mr. Mosher), Wallace Wolodarsky (M. Georges), Neal Huff (Lieutenant), Steffen Scheumann (Oberkellner (1968)), Tony Revolori (Zero), Bob Balaban (M. Martin), Volker Michalowski (Günther), Waris Ahluwalia (M. Dino), Léa Seydoux (Clotilde), Giselda Volodi (Serge's Schwester), Florian Lukas (Pinky), Karl Markovics (Wolf), Fisher Stevens (M. Robin)