Jeff Goldblum (David Levinson), Bill Pullman (Thomas J. Whitmore), Liam Hemsworth (Jake Morrison), Jessie Usher (Dylan Dubrow-Hiller), Maika Monroe (Patricia Whitmore), Sela Ward (Präsidentin Lanford), Charlotte Gainsbourg (Dr. Catherine Marceaux), Vivica A. Fox (Jasmine), William Fichtner (General Adams), Brent Spiner (Dr. Brakish Okun), Judd Hirsch (Julius Levinson), Ryan Cartwright (Officer Ryan Collins), Joey King (Sam), Angelababy (Rain Lao), Jonathan Buckhouse (Fußgänger), Garrett Wareing (Bobby), Gbenga Akinnagbe (Agent Matthew Travis), Chin Han (Commander Jiang Lao), Mckenna Grace (Daisy), Patrick St. Esprit (Verteidigungsminister Tanner), Lance Lim (Kevin), Alice Rietveld (Secret Service-Agent), Grace Huang (Lin Tang), Hays Wellford (Felix), Deobia Oparei (Dikembe)