Chris Pine (Jack Ryan / Cornerback), Kevin Costner (Thomas Harper), Kenneth Branagh (Viktor Cherevin), Keira Knightley (Cathy Muller), Lenn Kudrjawizki (Constantin), Nonso Anozie (Embee Deng), Colm Feore (Rob Behringer), Gemma Chan (Amy Chang), David Paymer (Dixon Lewis), Karen David (FBI-Chefagentin), Mikhail Baryshnikov (Innenminister Sorokin), Alec Utgoff (Aleksandr Borovsky), Aleksandar Aleksiev (Cherevins Leibwächter), Andrew Byron (Cherevins Leibwächter), Derek Lea (Cherevins Leibwächter), Angus Wright (großer Mann), Elena Velikanova (Katya), Peter Andersson (Dimitri Lemkov), Georg Nikoloff (Van-Fahrer (T-Bone)), Mike Noble (Junior Analyst), Mike Houston (CIA-Agent), Nick Court (Feldarzt), Parker Sawyers (USMC-Sanitäter), Akie Kotabe (Helfer)