Daniel Craig (James Bond), Christoph Waltz (Ernst Stavro Blofeld / Franz Oberhauser), Léa Seydoux (Madeleine Swann), Ralph Fiennes ('M'), Ben Whishaw ('Q'), Monica Bellucci (Lucia Sciarra), Dave Bautista (Mr. Hinx), Naomie Harris (Moneypenny), Andrew Scott ('C'), Rory Kinnear (Bill Tanner), Jesper Christensen (Mr. White), Stephanie Sigman (Estrella), Alessandro Cremona (Marco Sciarra), Domenico Fortunato (Gallo), Ian Bonar (Qs Assistent), Alessandro Bressanello (Priester), Marc Zinga (Moreau), Brigitte Millar (Dr. Vogel), Adel Bencherif (Abrika), Peppe Lanzetta (Lorenzo), Francesco Arca (Francesco), Matteo Taranto (Marco), Erick Hayden (Marshall), Pip Carter (SC019 Police Commander), Simon Lenagan (SC019 Police Officer)