Rowan Atkinson (Johnny English), Gillian Anderson (Pamela Thornton (Pegasus)), Dominic West (Simon Ambrose), Rosamund Pike (Kate Sumner), Daniel Kaluuya (Agent Colin Tucker), Richard Schiff (Titus Fisher), Tim McInnerny (Patch Quartermain), Togo Igawa (Obermönch Ting Wang), Burn Gorman (Slater), Christina Chong (Barbara), Ian Shaw (Agent Nummer Zwei), Isla Blair (Shirley), Miles Jupp (MI7-Labortechniker), Pik-Sen Lim (Killer-Putzfrau), Stephen Campbell Moore (Premierminister), Joséphine de La Baume (Madeleine), Mark Ivanir (Karlenko), Rupert Vansittart (Derek), Williams Belle (Ling), Chris Jarman (Michael Tembe), Mariella Frostrup (Royce), Emma Vansittart (Margaret), Eric Carte (Agent #1), Roger Barclay (Agent #2)