Sam Worthington (Perseus), Liam Neeson (Zeus), Ralph Fiennes (Hades), Jason Flemyng (Acrisius / Calibos), Alexa Davalos (Andromeda), Gemma Arterton (Io), Mads Mikkelsen (Draco), Luke Evans (Apollo), Liam Cunningham (Solon), Pete Postlethwaite (Spyros), Elizabeth McGovern (Marmara), Tamer Hassan (Ares), William Houston (Ammon), Polly Walker (Cassiopeia), Vincent Regan (Kepheus), Nicholas Hoult (Eusebios), Kaya Scodelario (Peshet), Hans Matheson (Ixas), Danny Huston (Poseidon), Alexander Siddig (Hermes), David Kennedy (Kepheus' General), Ashraf Barhom (Ozal), Graham Hughes (Deino), Martin McCann (Phaedrus), Katherine Loeppky (gealterte Cassiopeia), Sinead Michael (Tekla), Mouloud Achour (Kucuk), Luke Treadaway (Prokopion), Ian Whyte (Scheich Suleyman), Izabella Miko (Athena), Rory McCann (Belo), Robin Berry (Enyo), Ross Mullan (Pemphredo), Tine Stapelfeldt (Danae)