Colin Farrell (Sonny Crockett), Jamie Foxx (Ricardo Tubbs), Gong Li (Isabella), Naomie Harris (Trudy Joplin), Ciarán Hinds (Agent Fujima), Justin Theroux (Detective Larry Zito), Barry 'Shabaka' Henley (Castillo), Luis Tosar (Montoya), John Ortiz (Jose Yero), Elizabeth Rodriguez (Gina Calabrese), John Hawkes (Alonzo Stevens), Eddie Marsan (Nicholas), Isaach de Bankolé (Neptune), Domenick Lombardozzi (Detective Stan Switek), Tom Towles (Coleman), Tony Curran (Aryan Brother), Mario Ernesto Sánchez (El Tiburon), Frankie J. Allison (breitschultriger Aryan Brother), Don Frye (langhaariger Aryan Brother), Chris Astoyan (Agent Perry), Ana Cristina De Oliveira (Barfrau), Everlayn Borges (Miss Cuba)