Ben Stiller (Larry Daley / Laa), Robin Williams (Teddy Roosevelt), Owen Wilson (Jedediah), Ben Kingsley (Ägyptischer Pharao), Dan Stevens (Sir Lancelot), Ricky Gervais (Dr. McPhee), Rachael Harris (Madeline Phelps), Rami Malek (Ahkmenrah), Mickey Rooney (Gus), Rebel Wilson (Tilly), Dick van Dyke (Cecil Fredericks), Steve Coogan (Octavius), Skyler Gisondo (Nick Daley), Patrick Gallagher (Attila der Hunne), Matt Frewer (Archibald Stanley), Bill Cobbs (Reginald), Sayed Kassem (Assyrian), Percy Hynes White (C.J. Fredericks), Mizuo Peck (Sacajawea), Anjali Jay (Shepseheret), Crystal the Monkey (Dexter), Brennan Elliott (Robert Fredericks), Andrea Martin (Rose), Patrick Sabongui (Amir), Sophie Levy (Sophie)