Amy Adams (Susan Morrow), Jake Gyllenhaal (Edward Sheffield / Tony Hastings), Michael Shannon (Bobby Andes), Aaron Taylor-Johnson (Ray Marcus), Isla Fisher (Laura Hastings), Karl Glusman (Lou Bates), Armie Hammer (Hutton Morrow), Laura Linney (Anne Sutton), Andrea Riseborough (Alessia), Michael Sheen (Carlos), Neil Jackson (Christopher), Kristin Bauer van Straten (Samantha Van Helsing), Jack Wallace (alter Mann), Franco Vega (Fahrer), Lee Benton (Linda), Carson Nicely (Diener bei der Dinerparty), Ellie Bamber (Helen Hastings), Chelsea Taylor (junges Mädchen), Evan Bittencourt (Aufzugtechniker), Evan Charles (Alex - Dinergast), Amanda Fields (Besucherin in der Kunstgalerie), Robert Aramayo (Turk), Josh Ford (Geschäftsmann), Jonathan Fredrick (UPS-Mann), Nick Hounslow (Partygast), Maria Zyrianova (blonde Frau)