Joel Kinnaman (Alex Murphy / RoboCop), Michael Keaton (Raymond Sellars), Samuel L. Jackson (Pat Novak), Gary Oldman (Dr. Dennett Norton), Abbie Cornish (Clara Murphy), Jay Baruchel (Tom Pope), Jackie Earle Haley (Rick Mattox), Aimee Garcia (Jae Kim), Michael K. Williams (Jack Lewis), Jennifer Ehle (Liz Kline), Philip Akin (Dr. Alan), Daniel Kash (John Lake), Zach Grenier (Senator Hubert Dreyfus), Marianne Jean Baptiste (Chief Karen Dean), Stewart Arnott (Führer der Senatskammer), Patrick Garrow (Antoine Vallon), Douglas Urbanski (Bürgermeister Durant), Tattiawna Jones (Assistentin des Bürgermeisters), Steve Cumyn (Senator aus Ohio), Melanie Scrofano (Ehefrau des Mannes mit Prothesen), Adrian Griffin (Mann im weißen Mantel), Alex Mallari Jr. (junger Leutnant), Matt Cooke (General Monroe), Robert Thomas (John Biggs), K. C. Collins (Andre Daniels), Dwayne McLean (Thomas King), John Paul Ruttan (David Murphy)