Anthony Hopkins (Dr. Hannibal Lecter), Ralph Fiennes (Francis Dolarhyde), Edward Norton (Will Graham), Harvey Keitel (Jack Crawford), Emily Watson (Reba McClane), Mary-Louise Parker (Molly Graham), Philip Seymour Hoffman (Freddy Lounds), Anthony Heald (Dr. Frederick Chilton), Ken Leung (Lloyd Bowman), Frankie Faison (Barney Matthews), Madison Mason (Polizeibeauftragter), Bill Duke (Polizeichef), Lalo Schifrin (Dirigent), Michael Cavanaugh (Gerichtsmediziner), Tyler Patrick Jones (Josh Graham), Brenda Strong (Dinner-Gast), David Doty (Dinner-Gast), John Rubinstein (Dinner-Gast), Marc Abraham (Dinner-Gast), Mary Anne McGarry (Dinner-Gast), Robert Curtis Brown (Dinner-Gast)