Shia LaBeouf (Sam Witwicky), Rosie Huntington-Whiteley (Carly Spencer), Patrick Dempsey (Dylan Gould), Josh Duhamel (Lieutenant Colonel William Lennox), John Turturro (Seymour Simmons), Tyrese Gibson (Robert Epps), Alan Tudyk (Dutch), Kevin Dunn (Ron Witwicky), Julie White (Judy Witwicky), Frances McDormand (Charlotte Mearing), John Malkovich (Bruce Brazos), Ken Jeong (Jerry Wang), Glenn Morshower (General Morshower), Bill O'Reilly (er selbst), Buzz Aldrin (er selbst), Lester Speight (Eddie), Ravil Isyanov (Voshkod)