Ice Cube (Darius Stone / XXX), Willem Dafoe (General George Deckert), Samuel L. Jackson (Agent Augustus Eugene Gibbons), Scott Speedman (Agent Kyle Christopher Steele), Xzibit (Zeke), Peter Strauss (Präsident James Sanford), Michael Roof (Agent Toby Lee Shavers), Sunny Mabrey (Charlie Mayweather), Nona Gaye (Lola 'Lo' Jackson), John G. Connolly (Lieutenant Alabama 'Bama' Cobb), Ned Schmidtke (General Jack Pettibone), Paul Collins (NSA-Direktor Bill Brody), Bruce Kirkpatrick (Police Captain Davis), Thom Gossom Jr. (Baptistenprediger), Barry Sigismondi (Bull), Ramon De Ocampo (Agent Meadows), Scott Michael Morgan (Landarbeiter), Chris J. Johnson (junger Agent), Stan Sellers (verklemmter Geschäftsmann), Doug Campbell (Marine), Kent Shocknek (Nachrichtensprecher), Glen Walker (Nachrichtensprecher), Todd Louiso (Dickie Ambrose)